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Oxidative stress and free radicals to affect male fertility - qLIFE PRA
A research team led by dr hab. Wirginia Krzyściak carried out research seeking to identify biomarkers that assist in diagnostics and monitoring of male reproductive potential.
A combined assessment of oxidative-anitoxidant indicators has been performed for malondialdehyde (MDA), glutathione (GSH) and total redox antioxidant potential (TRAP – Total Radical-Trapping Antioxidant Parameter : ability of the cells to protect themselves against free radicals) of semen plasma, coupled with a seminogram (assessment of spermatozoa and the fluids produced by the prostate and the seminal vesicles), and the assessment of clinical condition and lifestyle in patients with reproductive problems.
The combined assessment of GSH and TRAP as potential biomarkers of male infertility in seminal plasma showed the highest total sensitivity and specificity.
Moreover, the evidence gathered shows that male reproductive potential is significantly correlated with basic sperm parameters, sperm cell membrane integrity, their morphology, lifestyle, eating habits, occupation, and mental health.
The results provide evidence to the importance of oxidative stress and defence against free radicals in diagnosing and monitoring infertility in men. The research team led by dr hab. Wirginia Krzyściak has presented an alternative approach to the possibility of interpreting combinations of a number of biomarkers that can bring benefits to a multi-threaded approach to the diagnosis and treatment of male infertility.
TRAP – total redox antioxidant potential – the system’s capacity to protect itself against free radicals, consisting in reducing them to substances with a neutral charge.
Biomarkers – biological marker – an objectively measurable biological indicator (a gene, a physiological trait) that can suggest a disease state.
Publication available at:
https://www.mdpi.com/2077-0383/9/6/1785
The publication has been funded from the budget of the qLife Priority Research Area under the Strategic Programme Excellence Initiative at the Jagiellonian University.
The article on the qLIFE PRA website:
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