Antibacterial properties of gold and silver nanoparticles on graphene surfaces - the qLIFE PRA
The interaction between bacteria and nanoparticles is currently the main area of interest in bionanotechnology research. A group of researchers1 examined the opposite effects of functionalization with gold and silver (Au and Ag) (AuNPs and AgNPs, ~ 25 nm) on bacterial attachment to model graphenic surfaces. The nanoscale functionalization of the graphenic surface resulted in bacterial adhesion (AuNP) and bactericidal activity (AgNP). The trends observed by the researchers provide an overall insight into the interactions between bacteria, nanoparticles and the surface as they have been seen among both gram-negative (Escherichia coli and Pseudomonas aeruginosa) and gram-positive (Staphylococcus aureus and Staphylococcus epidermidis) strains. It is worth noting that the simultaneous deposition of AuNP and AgNP performed two functions, enhancing both bacterial adhesion and antimicrobial potential. The antimicrobial properties of AgNPs have been explained in terms of electronic effects. Their deposition on graphene has led to the formation of reactive oxygen species (ROS), which react with the walls of bacterial cells and destroy them effectively.
Conducting these research was possible thanks to the purchased fluorescence microscope (funded by the qLIFE PRA), which allowed to assess the adsorption of bacteria on graphene and the survival of microorganisms on its surface functionalized with Au and/or Ag nanoparticles.
On the basis of research mentioned above, a scientific article was published: Opposite effects of functionalization with gold and silver nanoparticles on bacterial attachment to graphenic surfaces. The article is included in the review for the Surfaces and Interfaces journal.
1Corresponding Author: Prof. Andrzej Kotarba - Faculty of Chemistry at Jagiellonian University; Co-Authors: Wojciech Pajerski; Paulina Chytrosz; Monika Gołda-Cępa; Mirosław Pawlyt; Witold Reczyński; Dorota Ochońska (WL); Monika Brzychczy-Włochy (WL).
The purchase of the devices has been funded from the budget of the qLIFE Priority Research Area under the Strategic Programme Excellence Initiative at Jagiellonian University.